1226: Evaluation of Procalcitonin-Guided Antibiotic Therapy in Sepsis and Septic Shock
نویسندگان
چکیده
منابع مشابه
Procalcitonin-guided therapy in severe sepsis and septic shock
We read with interest the recent systematic review of procalcitonin-guided therapy in intensive care unit patients with severe sepsis and septic shock [1]. We congratulate and applaud their important work, but several important issues should be noted. First, the authors failed to include a relevant randomized controlled trial in their meta-analysis [2], although it apparently met their inclusio...
متن کاملProcalcitonin-guided algorithm to reduce length of antibiotic therapy in patients with severe sepsis and septic shock
BACKGROUND Procalcitonin (PCT)-protocols to guide antibiotic treatment in severe infections are known to be effective. But less is known about the long-term effects of such protocols on antibiotic consumption under real life conditions. This retrospective study analyses the effects on antibiotic use in patients with severe sepsis and septic shock after implementation of a PCT-protocol. METHOD...
متن کاملProcalcitonin-guided therapy in intensive care unit patients with severe sepsis and septic shock – a systematic review and meta-analysis
INTRODUCTION Procalcitonin (PCT) algorithms for antibiotic treatment decisions have been studied in adult patients from primary care, emergency department, and intensive care unit (ICU) settings, suggesting that procalcitonin-guided therapy may reduce antibiotic exposure without increasing the mortality rate. However, information on the efficacy and safety of this approach in the most vulnerabl...
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There has been little improvement in septic shock mortality in the past 70 years, despite ever more broad-spectrum and potent antimicrobials. In the past, resuscitative elements have been the primary area of clinical septic shock management and research. The question of the optimal use of antimicrobial therapy was relatively ignored in recent decades. This review explores the pathophysiology of...
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In critically ill patients, elucidating those patients with the systemic inflammatory response syndrome (SIRS) from an infectious source (sepsis), versus those who have SIRS without infection, can be challenging since the clinical features are the same. Even with strict monitoring and testing, 39-98 % of patients with SIRS will never have bacteriological confirmation of an infection, and 6-17 %...
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ژورنال
عنوان ژورنال: Critical Care Medicine
سال: 2020
ISSN: 0090-3493
DOI: 10.1097/01.ccm.0000730792.58678.2a